Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive genetic disorder causing a defect in cholesterol synthesis that results in delays in all areas of development and may be complicated by one or more congenital malformations. SLOS is a life-long disorder with no cure and limited treatment options. It is often misunderstood. Many individuals who have the syndrome remain undiagnosed for long periods of time or indefinitely.
It is the goal of the Smith-Lemli-Opitz Foundation to fund research that addresses these issues. Therefore the Foundation seeks and accepts proposals for research into furthering any knowledge related to SLOS.
The Smith-Lemli-Opitz Foundation believes in funding research that moves us closer to understanding the nuances of SLOS, providing new treatments for those affected, and ultimately finding a cure for this rare genetic syndrome.
Research proposals up to $25,000 (USD) and two years in scope (preferably only a single year) for any aspect related to SLOS are accepted and reviewed by our Medical & Scientific Advisory Board.
Our primary interest is funding experienced investigators testing initial hypotheses and preliminary data collection (often considered “seed money”). This can lead to long-term funding by major granting institutions.
Another goal is to continually attract new and/or young investigators into the exciting field of SLOS research.
Please review the Grant Application Guidelines below and submit your request to the address contained therein.
Upon receipt of the application, it will be distributed to the Medical & Scientific Advisory Board for review.
The Board of Directors will then make a decision based on their own review and the advisement of the MSAB.
Questions? Contact: Dr. Michael Cohen, Director of Research for the SLO Foundation at mc******@gm***.com • or
Thank you for your interest in research. Our Smith-Lemli-Opitz Foundation network of families and professionals truly appreciates it!
Grant applications need to be submitted throughout the calendar year.
The application should be no longer than 15 pages of type 12 font and 1 inch margins (exclusive of budget and other requested documents) and must be in English. It should include the following:
An information page which lists:
Completed proposals are reviewed by the Smith-Lemli-Opitz Foundation Medical Advisory Board for evaluation and interpretation. Final determination is made by the Board of Directors based on the recommendations of the Medical Advisory Board.
Applications are evaluated on the following:
We welcome names and contact information for individuals you feel would be appropriate outside reviewers. They must be qualified to review the proposal, have no conflict of interest and have not worked with you in the last two years.
notification of acceptance or denial is typically given by May 1st.
If the grant is approved a letter of approval will be sent to the applicant and funds will be available for immediate disbursement.
Funded research proposals must provide the following:
The Smith-Lemli-Opitz Foundation reserves the right to publish some basic information about the research grant proposals such as: title, principal investigator, institution, amount requested and/or rewarded and the abstract summary. No trade secrets or confidential information identified as such will be made public.
The Principal Investigator and the grantee Institution indemnify and hold harmless the Smith-Lemli-Opitz Foundation, its Board Members, Officers, agents, advisors and constituents from any claim judgment, award, damage, settlement, liability, negligence or malpractice arising from research related to the research grant.
The agreement between parties is a funding agreement only.
If you have any questions about the application process, please contact us at no**@sm*************.org or contact Gretchen Noah at +1-701-367-1976. When an application has been submitted and reviewed, you will be notified of a final decision regarding the grant.